HP1α is an isoform of the heterochromatin protein 1 (HP1) which plays a role in chromatin remodeling and transcriptional silencing. The HP1 chromo domain selectively recognizes methylated H3-K9, where this methylation is carried out by histone methyltransferase SUV39H1. SUV39H1-HP1 methylation is important for the correct localization of HP1 at heterochromatin and for transcriptional silencing.
Affinity purified goat polyclonal antibody to HP1a (heterochromatin protein 1 alpha, HP1 alpha)
Protein A purified
HP1a, HP1-a, HP1α, HP1-α
Mouse, rat, human
0.1% Sodium Azide, 0.1% gelatin, PBS
4ºC, stable for 1 year from the date of shipment. Avoid repeated freezing and thawing. Multiple freeze/thaw cycles may result in decreased performance
Antigen p25 antibody, Cbx 5 antibody, CG8409 antibody, Chromobox homolog 5 (Drosophila HP1 alpha) antibody, Chromobox protein homolog 5 antibody, Heterochromatin protein 1 alpha antibody, HP 1 antibody, HP 1A antibody, HP1Hs alpha antibody, Su(var)205 antibody
WB: 1:200-1:500, IF: 1:100-1:500, ELISA: 1:500-1:1000
Fig. 1. WB analysis of HP1α Polyclonal Antibody with MCF-7 cell lysates (A-4015).