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DNMT1 Monoclonal Antibody [60B1220.1]

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Application: ChIP, ELISA, IF, IP, WB
Clonality: Monoclonal
Conjugate: Unconjugated
Host: Mouse
Isotype: IgG1
Purification: Affinity Purified
Reactivity: Human, Mouse
Application Guarantee: 6 months
Catalog No.SizePriceQty
A-1001-05050 µg $199.00 
A-1001-100100 µg $369.00 
Availability: Usually Ships in 1 Day or Same day delivery Same Day NY Delivery 
Product Overview

Background
DNA Methylation at cytosine residues has a role in regulation of gene expression, genomic imprinting and is vital for mammalian growth. Hypermethylation of CpGisland in tumor repressor genes or hpyomethylaiton of mass genomic DNA has been linked to cancer development. Three families of DNMT genes are known which include DNMT1, DNMT2 and DNMT3. DNMT1 is constitutively expressed in proliferating cells and inactivation of this gene causes global demethylation of genomic DNA and embryonic death. DNMT1 also cooperates with Rb to repress transcription from promoters containing E2F-binding sites indicating a link between DNA methylation, histone deacetylase and sequence-specific DNA binding activity, as well as a growth-regulatory pathway which is abnormal in nearly all cancer cells.

Concentration
0.5 mg/ml

Description
Mouse monoclonal antibody to Dnmt1, clone 60B1220.1, ChIP-grade

Purification
Protein A purified

Specificity
Mouse, Human

Isotype
IgG1

Formulation
0.05% Sodium Azide, 0.2% Gelatin, PBS

Storage
4ºC, stable for 1 year from the date of shipment. For long-term storage, aliquot and store at -20ºC. Avoid repeated freezing and thawing. Multiple freeze/thaw cycles may result in decreased performance

Alternative Names
ADCADN antibody, AIM antibody, CXXC finger protein 9 antibody, CXXC-type zinc finger protein 9 antibody, CXXC9 antibody, DNA (cytosine-5)-methyltransferase 1 antibody, DNA methyltransferase 1 antibody, DNA methyltransferase HsaI antibody, DNA methyltransferase M.HsaI. antibody, DNA MTase antibody, DNA MTase HsaI antibody, DNMT 1 antibody, DNMT antibody, Dnmt1 antibody, DNMT1_HUMAN antibody, Dnmt1o antibody, FLJ16293 antibody, HSN1E antibody, M.HsaI antibody, MCMT antibody, Met1 antibody, MGC104992 antibody, mMmul antibody, MommeD2 antibody

Application
WB: 1:250; IF: 1:100-1: 500; ELISA: 1:1000-1:2000, IP: 2 μg/106 cells

Fig. 1. WB analysis of DNMT1 Monoclonal Antibody (A-1001, 1:1000) with use of Hela cell extracts. 

User Guide & MSDS

[User Guide]*
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