This gene is involved in transcription repression and activation. It can repress transcription independently of histone deacetylase activity and is targeted to replication foci throughout S phase by directly interacting with the N-terminus of DNA methyltransferase 1. Its interaction with HDAC2 may provide a means for histone deacetylation in heterochromatin following replication of DNA at late firing origins. In addition, the encoded protein is a component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes, primarily through acetylation of H4 and H2, and plays a primary role in transcription, cellular response to DNA damage, and cell cycle control.
Rabbit polyclonal antibody to DMAP1
Protein A purified
Tested in humans
0.1% Sodium Azide, PBS
4°C, stable for 6 months from the date of shipment. For long-term storage, aliquot and store at -20°C. Avoid repeated freezing and thawing. Multiple freeze/thaw cycles may result in decreased performance
DKFZp686L09142 antibody, DMAP 1 antibody, DNA methyltransferase 1-associated protein 1 antibody, DNMAP 1 antibody, DNMT1-associated protein 1 antibody, DNMTAP 1 antibody, EAF 2 antibody, FLJ11543 antibody, KIAA1425 antibody, MAT 1-mediated transcriptional repressor antibody, MGC55593 antibody, SWC 4 antibody, zgc:55593 antibody
WB: 1:200-1:500; IHC: 1:100, ELISA: 1:1000-1:2000
Fig. 1. WB analysis of DMAP1 antibody with HL60 cell lysatess (A-1011).